Parametric (@parametricpbc) is deploying intelligent, low-cost robots that do work how you want it, lowering the barrier to entry for businesses to leverage autonomy.
Congrats on the launch, @c0dyswain & @jnewsom98!
https://t.co/AlQH6MWksW https://t.co/3AcMt6uAg0
Sim (@simdotai) is building the visual, end-to-end agent builder — a platform where developers can design, test, and deploy real AI agents that work in production.
Founded earlier this year, Sim grew from a small San Francisco apartment to a community of 60,000 developers and 18,000 GitHub stars, recently raising a $7M Series A.
Co-founder & CEO @emkara sat down with YC’s @aaron_epstein to share how they’re building the infrastructure for the agent era, and what it takes to create AI systems that reason, retrieve, and act safely at scale.
00:36 – What Sim Does and Why It Matters
02:05 – From a SF Apartment to 60,000 Devs
04:20 – Finding Early Users and Product-Market Fit
07:05 – Designing an End-to-End Platform for Agents
10:30 – Powering the Open Source Agent Ecosystem
13:25 – Raising a $7M Series A
16:20 – Building Agents That Actually Work
20:10 – The Infrastructure for the Agent Era
23:40 – Advice for Builders in AI
Kaigo Health (@kaigohealth) is building an AI care workforce that looks after Grandma and Grandpa— helping healthcare providers keep patients healthy at home by automating the follow-ups, check-ins, and monitoring that often fall through the cracks. https://t.co/nLD8Eq35CW
Inspector (@tryinspector) is an AI IDE for front-end that connects browser and codebase.
It lets you select elements visually and prompt changes, giving coding agents access to the same runtime context developers have: visuals, elements, and logs. https://t.co/QnTISmnc24
With 15M downloads and 500+ enterprise clients, @Speak has passed $100M in annualized revenue.
Users practice speaking 5-10x more on Speak than on other language apps, through AI-powered roleplays & real-world scenarios.
https://t.co/j8PQ8Hmxdb
Prox (@try_prox) builds digital co-workers for 3PLs and fulfillment centers - companies that store, pack, and ship for brands.
They automate the back-office operations layer that burns billions of labor hours across the industry. https://t.co/RDHVJfPXpV
LogosGuard (@logos_guard) is building the risk management software for enterprises adopting AI.
Stress-test your AI products, continuously monitor compliance with your controls, and gain the confidence to deploy AI responsibly.
Congrats on the launch, @abelpjohn & @sukrut_oak!
https://t.co/R5ubFkgSGn
Why can’t marketing AI help marketers the way coding AI helps software engineers? @HightouchData thinks it can.
They just launched Hightouch Agents, an AI platform purpose-built for marketers.
It combines full marketing context with pre-built marketing skills, giving marketers the same productivity boost that coding assistants gave engineers.
https://t.co/kwhcFxlW1c
Proxis (@proxis_ai) writes and sends emails in your voice.
It connects to your inbox + CRM + Notion + Drive + Slack so replies are accurate, on-brand, and auto-sent when confident.
Congrats on the launch, @liam_a_collins!
https://t.co/7cRpUrXgic https://t.co/9UgGreMPgq
Multifactor (@MultifactorCOM) is building the future of zero-trust authentication, authorization, and auditing for AI agents.
Their platform lets users securely and revocably share any online account with humans and AI agents alike, just by sending a link. https://t.co/V313zcyCFo
Lakonia (@LakoniaTech) is an AI-powered command and control platform for law enforcement and the military.
It transcribes radio communications, analyzes them, and then synthesizes information for commanders/dispatchers and operators to act on.
https://t.co/0Gha1bn33w
Congrats on the launch, @grdysun & @thejustinoh!
Congrats to Mecha Health on their $4.1M seed!
They’re building next-gen foundation models for healthcare, starting with medical imaging. Mecha Health's systems help radiologists work faster and with greater accuracy, without feeling like they’re doing more work.
https://t.co/bSUYgKkf5h
Moss (@usemoss) is the real-time semantic search for conversational AI. By bringing retrieval latency under 10 ms, Moss makes AI conversations feel natural, as fluid and instant as talking to a human.
https://t.co/UtnwaJZVNY
Congrats on the launch, @srimalireddi & @ImHarshaNalluru!
From dorm rooms to million-dollar companies.
You can just do things. And YC can help.
Apply to W26 by November 10: https://t.co/gNl84ElBrq https://t.co/IcpiCB1lNo
Unsiloed AI (@UnsiloedHQ) builds APIs to parse multimodal unstructured data like PDFs, PPTs, and images and convert it into LLM-ready formats like markdown and JSON.
https://t.co/f4RJStJIcE
Congrats on the launch, @__Aman_Mishra & Adnan! https://t.co/wgEvXw8wj7
Sciloop (@SciloopAI) automates the entire scientific research loop from hypothesis generation to experiment design, execution, analysis, iteration— and drafts real research papers.
https://t.co/r1FbEEsymk
Congrats on the launch, @bilalasmat04 & @OsmanSiddiquer! https://t.co/Joyoks9w6v
Congrats to @Starcloud_Inc1 on the launch of their first satellite, just 21 months from starting the company.
This is the first NVIDIA H100 in space and paves the way for huge, solar-powered orbital data centers.
https://t.co/ROxgwTOdP2
AnswerThis (@answerthisio) is the AI assistant that helps researchers find, analyze, and write research papers.
Over 250k researchers visit https://t.co/n4pWiYjHyS monthly to go from research question to publication on one workspace. https://t.co/CSkZcXirW5
Narrative (@narrativevideo) is Cursor for video editing.
Narrative is the AI video editor that automates the tedious parts, like searching footage, pulling selects and syncing cameras— so pros can edit hours of content in minutes. https://t.co/FsxR3v0CiP
Locus (@paywithlocus) gives your AI agents the ability to spend without losing control. A secure way to connect your agents to funds, with identities, budgets, and permissions.
Make them pay: for anything, anywhere.
https://t.co/Sw9dURzTLS
Congrats on the launch, @coledermo & @eliotlee33!
Aside (@AsideAI) shows live suggestions during sales calls, helping sales reps answer technical questions.
Connect your docs, Slack, and past winning calls — Aside surfaces the right answer in 0.8s. No more “Let me get back to you.” https://t.co/fbWzP2caKy
Dome (@GetDomeAPI) is a unified API for prediction markets like Polymarket and Kalshi. Trade and analyze data across multiple platforms with one simple API.
https://t.co/YsZk6Elw2Y
Congrats on the launch, @kurushdubash & @princeofbothell! https://t.co/MxUm8aAQEE
RT @dflieb: >Sick video guys. Did you make it with Velvet?
>Yup!
>How long did it take?
>Oh, a morning maybe
>How much did the credits co…
Velvet (@Velvet_Videos) is building the Adobe Premiere of AI video, allowing creative teams to generate and edit dozens of cinematic AI videos in seconds.
https://t.co/lYvqpwSEXb
Congrats on the launch, @lrmantovani_ & @luke_tux!
(They made this launch video using Velvet by spending ~$50 in credits in ~5 hours)
Some of the biggest breakthroughs, like OpenAI and SpaceX, started as ideas most people thought were impossible.
But the best founders stay contrarian long enough to be right, learning from criticism but staying true to their convictions and users who believe in the same vision. https://t.co/PTLjdPfoCW
Pixley (@PixleyAI) turns kids’ drawings into personalized animated cartoons that teach and entertain. Hundreds of families have brought their stories to life on Pixley, making it the go-to platform for edutainment.
Congrats on the launch, @PranitAgrawal4 & @Krish5Iyengar! https://t.co/V5PEvD4UnH
BrowserOS (@browserOS_ai) is an open-source, privacy-first alternative to ChatGPT Atlas & Perplexity Comet.
No vendor lock-in: use any LLM or search engine AI agents run locally. No tracking you for ads or data collection. Available for Mac/Win/Linux.
https://t.co/GOYf9AzthL
Congrats on the launch, @nv_sonti, @ThatNithin!
.@1stcollab is a fully-automated, ROI-optimized influencer marketing platform that helps brands test, optimize, and scale influencer campaigns with just a few minutes of setup.
It already powers some of the largest influencer marketing campaigns on social media.
https://t.co/STbw7FTvGm
.@RiveterHQ is replacing the entire scraper infrastructure stack with a single API.
Their all-in-one search agent replaces SERP, scrapers, proxy managers, and more. And it knows which tools to use to find exactly the data you’re looking for.
https://t.co/WN3adWx2l5
Congrats on the launch, @agrillz and @codyetc!
MarkIt is building AI agents for trade compliance—helping suppliers, importers, and customs brokers classify products, manage documents, and navigate government requirements.
https://t.co/tTaCTxaPR9
Congrats on the launch, @ch6nkim and @supadupacoda! https://t.co/cxhpOAGgFV
AutoAce (@AutoAce_AI) is the AI-native operating system for car dealerships, starting with voice agents that automate calls, bookings, and updates across service, sales, parts, and F&I.
They're already driving six-figure revenue gains for dealerships. https://t.co/Zz7vP4sWjl
Congrats to @alexchantavy, @kunaalsikka, and @SubImageSec on their $4.2M seed!
From the creators of Cartography at @Lyft, SubImage is an open-core alternative to Wiz, using AI to show how vulnerabilities and access paths lead to compromise.
https://t.co/HpMp0e8sfN https://t.co/KMyFtUYNkC
Congrats to @akeed23, @twopac, and @cerclihq on their $12M Series A!
Cercli is the single platform for enterprises to hire, manage, and pay their global workforce in the AI era. They've grown 10x over the last 12 months, processed over $100M in payroll across 50 countries - and are now launching their AI-native recruitment product to help customers hire more intelligently.
https://t.co/jgb8L9r4lC
Congrats to https://t.co/c9C4WZdYZj on their $10.6M Series A!
Letter AI's enablement platform helps sales teams ramp up faster with AI-powered training and coaching, instantly find and personalize collateral for customers, and engage their buyers.
https://t.co/mX4rRd1JVo https://t.co/mIGGfzxkUE
Every founder faces moments where they’re not sure what to do next — such as how to go to market with AI products, when to pivot, and who/when to hire.
In this episode of Office Hours, YC partners @koomen, @bradflora, @dessaigne, and @gustaf answer real questions from founders and share stories about how great teams build conviction, learn faster, and make better decisions as they grow.
0:36 - Building an AI company in a legacy industry
7:00 - Time to grow vs long-term defensibility
14:31 - Spending for temporary edge vs waiting for model leap
16:10 - When should you consider pivoting if you’ve got traction?
26:07 - The power of technically challenging problems
30:42 - When to start hiring?
35:18 - When is it a good idea to open source an enterprise SaaS product?
Freeport (@Freeportmkts) builds intelligent, research-backed crypto portfolios — integrating the best of DeFi to earn real yield, diversify across trusted assets, and stay in self-custody.
No fees, no noise. One page, one click.
https://t.co/XOFhsziMX0
Congrats on the launch, @Lihong062 & @brybryman!
Metorial (@MetorialAI) makes it easy for AI agents to use tools and data.
Deploy 600+ MCP integrations in three clicks and connect them to agents in a single function call. Open-source and the only serverless MCP platform built for multi-tenant systems. https://t.co/YPpAcSw1J5
https://t.co/UlyECkLph4 is the all-in-one platform built for real builders. Keep teams aligned, simplify every workflow, and bring trust back to construction.
Better than Procore. Cheaper than a truck.
https://t.co/CQWYQmzOja https://t.co/soAZZ949Pv
📧@mailmodo AI is an end-to-end conversational agent for email marketing.
Now startups can plan, design, automate, and analyze entire email campaigns in one conversation.
https://t.co/RVySuUbWw6 https://t.co/ZtXU78Kbpw
“Curiosity is the best guide. Your curiosity never lies, and it knows more than you do about what’s worth paying attention to.”
Paul Graham on How to Do Great Work: https://t.co/Tv7W8Lqx0v
Nine out of ten people might tell you you're crazy. The tenth might see what you see.
This week on the Lightcone, @garrytan, @harjtaggar, @snowmaker, and @sdianahu discuss contrarian bets — the ideas that look impossible until they work. From Uber and Coinbase to DoorDash and Flock Safety, they share how founders find opportunity where others see dead ends.
0:00 - Intro
2:00 - AI verticals are becoming more crowded
6:22 - Non-obvious successes
9:50 - End users can get regulations changed
18:05 - Finding contrarian ideas, what founders should look for
25:10 - Flock Safety and selling to local governments
33:40 - The sci-fi founder and "impossible" big ideas
36:42 - Outro
Congrats to @zeptonow on the $450M round at $7B valuation!
Zepto is dominating India's quick-commerce market with 1.7M daily orders (up from 500k five quarters ago). They're now operating 1,000+ dark stores across 80+ cities, with 10M+ new monthly users.
https://t.co/XI4ZhfiTHd
Helion (@Helion_Energy) just secured a Conditional Use Permit to start the next phase of construction of Orion, the world’s first commercial fusion power plant.
They're on track to deliver fusion power to Microsoft's grid by 2028. https://t.co/LjqXDhDod4
Semble AI automates fire-system design for construction companies.
It used to take billions of dollars and thousands of hours of manual drafting, building code lookups, and back-and-forth with permitting authorities. With Semble AI, it takes 5 minutes.
https://t.co/fJLjwfMRYN https://t.co/qDiY9vmn4d
Congrats to @nova_credit on their $35M Series D!
Nova is building the credit bureau of the future—helping nearly 100M Americans with limited or no credit history access financial products. They're powering decisions for major banks and 7,000+ businesses.
https://t.co/RqPFtYNKAN
Alai (@getalai) helps you create high-quality presentations faster.
Designed for iteration, quality, and speed, Alai turns rough ideas into decks you’re proud to present.
https://t.co/pTcHjdiApn https://t.co/fX5t8ggpLd
Congrats to @john__glasgow and @Meet_campfire on their $63M Series B!
Campfire is building the AI-native ERP for finance & accounting teams. They're reimagining how finance teams work, helping them close 5× faster and reclaim 144 days a year.
10× YTD growth. Customers migrated off SAP. Trusted by Replit, Decagon, PostHog, Heidi Health & Klarity.
https://t.co/9gx7Bnx8gd
Dedalus Labs (@dedaluslabs) is building the infrastructure layer for agentic AI—the simplest way to build and deploy complex agents across any model and any tool.
Congrats on the launch, @itsCathyDi & @WindsorNguyen!
https://t.co/vxjzXtA6tA https://t.co/djFsGAOWKx
Structured AI (@getstructuredai) is an AI workforce for pre-construction design engineering.
They save engineers 30% of their time by automating documentation and validating designs directly inside the software teams already use.
Congrats on the launch, @stingrayzz22, @Green181024 and @brandonstarxel!
Woz (@WithWoz1) has raised $6M to launch the first AI Product Factory.
AI prototyping is easy. Building apps that real businesses can trust? Not so much. Woz changes that. Start building your mobile app today: https://t.co/MurBc2oV2a
Congrats @BenjaminT007 & @ChefEckert on the seed and launch!
Fernstone is an AI-powered insurance brokerage for businesses.
Their platform handles the back and forth with carriers, autonomously files paperwork, and instantly responds to customer requests.
Congrats on the launch, @lukebbutton, @James_R_Chen, and @BryantLe18! https://t.co/iuDWVaTy8N
Hyperspell (@hyperspell) gives AI agents memory.
It connects to Slack, Gmail, Notion, and Drive, so agents get context and remember what they learn.
Congrats @conor_ai and @maebert on the launch!
https://t.co/WkfMWkUs5p https://t.co/BQj8QMpdkF
Canvas from @Spine_AI is an unlimited visual workspace for AI — where you can think, branch, and collaborate across hundreds of models.
Chat works for Q&A. Canvas is for thinking.
https://t.co/thZKTQWq0w
Congrats on the launch @BudhkarAkshay & @AshwinVRaman! https://t.co/vyaNLQE88D
Waydev AI (@waydevco) is the AI-native conversational platform for Engineering Intelligence.
Ask questions like “What’s our AI adoption rate?”, “How’s our cycle time trending?”, “Which teams drive the most impact?”
Instant insights, no dashboards.
https://t.co/b2YsuqATPI
After 1M+ downloads of their previous model, @nanonets is launching Nanonets-OCR2, a next-gen suite for image-to-markdown conversion & visual QA.
From LaTeX math & tables → mermaid charts, signatures → watermarks. It handles it all.
https://t.co/qK76htUkO6
.@Pulse__AI just launched Ultra Nano, their new enterprise-focused document extraction model with complete self-hosting, already running across Fortune 50s, insurers, investment firms, banks, and foundational model labs.
https://t.co/Yvoajxl8Gy
Congrats on the launch, @sid_mnk and @ritvikpandey21!
🐦@_claybird is an agent that plans, generates, and edits your AI video ad.
Marketers rely on slow, expensive agencies to produce ads. With Claybird, they go from idea to studio-quality ad in minutes.
https://t.co/PFE7rJVOPl
Congrats @_AbdullahNauman & @sadjamz_! https://t.co/5yANw2t8hj
Clicks (https://t.co/gxJWa7Xl6V) automates repetitive back-office work for recruiting & executive search firms, saving 60% on costs while reducing time-to-close.
Describe your process via video call or documentation, and they'll ensure it's automated exactly your way.
https://t.co/R6f6da7EYS
ComplyDo (@ComplyD0) automates how enterprises comply with hundreds of global regulations.
Already used by leading global players to replace months of manual work, reduce consulting hours, and accelerate market access. Without a fleet of consultants.
https://t.co/VpcLqrcbeT
Congrats on the launch, @SchuhmannLeo, Moritz, and Matthias!
Karri Saarinen (@karrisaarinen), co-founder and CEO of Linear, was the first designer at Coinbase and a lead designer at Airbnb.
On Design Review with YC's @aaron_epstein, he shares how his design background shaped Linear's product philosophy, why quality and craft matter from day one, what founders should look for when hiring, and how AI is changing the way teams build.
02:00 – Lessons learned from YC, Coinbase, and Airbnb
06:00 – Building trust through brand and design
08:24 – Linear’s brand: craft, quality, and authenticity
10:40 – Why sales is part of the brand experience
13:10 – Shipping fast without losing quality
17:18 – Hiring for product taste and judgment
19:28 – Superpowers of designers as founders
21:12 – Advice for designers considering founding a startup
23:26 – Why founders should care about design from day one
25:24 – Tips for creating products that stand out
28:24 – Balancing creative freedom with shipping timelines
28:56 – How AI is changing design and product work
30:44 – Why AI won’t replace designers (and what shifts to expect)
32:44 – The future of product and design teams with AI
Congrats to @furtheraicom on their $25M Series A!
By automating submission intake, policy comparison, claims processing, and compliance workflows, FurtherAI eliminates busywork so insurance professionals can focus on strategy and growth.
https://t.co/7UeMmkXBII
Amina from @AminoAnalytica is an AI agent for end-to-end protein engineering. Design novel therapeutics through conversation instead of wrestling with hundreds of fragmented tools.
Congrats on the launch @amino_abhi & @adaminoacid!
https://t.co/CSHjTvWgFL https://t.co/tm1izF2pnr
SlopeScore from @slopepay is the first cash flow score purpose-built for business lending, helping fintechs, banks, and lenders unlock more credit access for SMBs.
Congrats on the launch, @LawLM, @alicevdeng, and the Slope team!
https://t.co/KgUyMXR7k5 https://t.co/VhLZNLTtcJ
Cranston AI (@cranston_ai) does your company’s bookkeeping & taxes with AI.
Their agents pull in context from across the business and, after human review, file a full corporate tax return with the IRS.
https://t.co/Zg950m5cz8
Congrats on the launch @seanobannon_ & @MaxMinsker! https://t.co/MzCt7mxZq0
Your users want to chat with their data. Your engineers don't have 3 months to build it. @useCamelAI's embeddable API gives teams production-ready data chat in 5 minutes.
Congrats on the launch, @illiana_reed, @isabella_patane, and @Vercantez! https://t.co/9GTkPBjuP2
Jordan Fisher (@JordanFisherEzr) is the co-founder & CEO of Standard AI and now leads an AI alignment research team at Anthropic.
In his talk at AI Startup School, he frames the future of startups through questions rather than answers—asking how founders should navigate a world where AGI may be just a few years away.
0:00 – Why He's More Confused Than Ever
2:00 – Should You Even Start a Startup?
5:00 – Planning Beyond the Next Model
8:00 – Will Software Be Commoditized?
11:00 – Building AI-Native Teams
14:00 – Trust, Security, and Agents
18:00 – Auditing & Guardrails
21:00 – Alignment & Economic Pressure
24:00 – Data, Defensibility, and Hard Problems
28:00 – Neutrality and Control
32:00 – Changing the World vs. Just Making Money
36:00 – Build Something People Want (and Need)
39:00 – Audience Q&A
🪽@SafetyWing is launching health plans for US startups. Flat pricing, no deductible/co-pay, global coverage, including contractors.
https://t.co/q45wBvZ4a4 https://t.co/EVO82F1SvQ
Congrats to @useflai on their $4.5M seed round!
Flai helps automotive dealerships bring in more customers by handling all communication before they walk in the door — across calls, text, and email.
https://t.co/P5Yo4MZM64
Nexus (@nexus_gpt) helps non-technical teams build production-ready AI agents without code.
Orange's business team shipped an agent generating $4M+/month in just one week using Nexus.
https://t.co/AX1q8ijchT
Congrats on the launch, @achammah1 & @ShadyShoha! https://t.co/RupGQ6MNqj
In the early days, the only moat that startups have is speed. Once you make something people want, the question becomes what deeper moats can you build on to defend against the competition.
On the @LightconePod, @garrytan, @harjtaggar, @sdianahu, and @snowmaker dive into Hamilton Helmer’s Seven Powers framework to find out how these moats show up in practice today in AI startups.
00:00 - The Moat Problem
01:30 - The Seven Powers Framework
04:20 - When to Think About Moats
08:40 - Forward Deployed Engineering
10:18 - Process Power
14:34 - Cornered Resources
19:30 - Switching Costs
24:54 - Counter Positioning
31:24 - The Workforce Displacement Reality
34:00 - Brand & Speed as Moats
37:30 - Network Economies
41:00 - Scale Economies
43:44 - Final Advice